Prabha N. Ibrahim;Hanna Cho;Songyuan Shi;Guoxian Wu;Wayne Spevak
发明人:
Prabha N. Ibrahim,Wayne Spevak,Hanna Cho,Songyuan Shi,Guoxian Wu
申请号：
US12773798
公开号：
US08198273B2
申请日:
2010.05.04
申请国别(地区):
US
年份:
2012
代理人:
摘要：
Compounds and salts thereof, formulations thereof, conjugates thereof, derivatives thereof, forms thereof and uses thereof are described. In certain aspects and embodiments, the described compounds or salts thereof, formulations thereof, conjugates thereof, derivatives thereof, and forms thereof are active on each of BRaf and c-Raf-1 protein kinase, and may also be active on either or both of A-Raf and B-Raf V600E protein kinase. Also described are methods of use thereof to treat diseases and conditions, including melanoma, colorectal cancer, thyroid cancer, ovarian cancer, and biliary tract cancer.
