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IMMUNOMODULATING PROTEINS
专利权人:
ЛИВЕРПУЛЬ СКУЛ ОФ ТРОПИКАЛ МЕДИСИН (GB)
发明人:
ПЛИСС Ричард Джон (GB)
申请号:
RU2015118063
公开号:
RU2015118063A
申请日:
2012.10.17
申请国别(地区):
RU
年份:
2016
代理人:
摘要:
1. A method for treating an autoimmune or inflammatory disease in a mammal, the method comprising administering to the mammal an effective amount of a polymer protein containing five, six or seven polypeptide monomeric units, wherein each polypeptide monomeric unit contains an Fc receptor binding site containing two constant regions of an immunoglobulin heavy chain G; in this case, each constant region of the heavy chain of immunoglobulin G contains a cysteine residue, which is linked through a disulfide bond to the cyst new residue heavy chain constant region polypeptide immunoglobulin G adjacent monomeric unit; wherein the protein polymer contains additional immunomodulatory portion or portion of the antigen, which causes antigen-specific immunosuppression when administered to a subject-mlekopitayuschemu.2. The method of claim 1, wherein each polypeptide monomeric unit comprises a tail region fused to each of two constant regions of an immunoglobulin G heavy chain; while the tail portion of each polypeptide monomeric unit facilitates the assembly of monomeric units into a polymer. 3. The method of claim 2, wherein the tail portion is a tail portion of IgM or IgA, or a fragment thereof, or variant. The method according to claim 1, wherein each of the constant regions of the heavy chain of an immunoglobulin G contains an amino acid sequence having at least 90% identity with the sequence of the constant region of the heavy chain of a native human immunoglobulin G1. The method of claim 1, wherein each of the constant regions of the immunoglobulin G heavy chain contains an amino acid1. Способ лечения аутоиммунного или воспалительного заболевания млекопитающего, при этом способ включаетвведение млекопитающему эффективного количества полимерного белка, содержащего пять, шесть или семь полипептидных мономерных звеньев;при этом каждое полипептидное мономерное звено содержит участок связывания Fc-рецептора, содержащий две константные области тяжелой цепи иммуноглобулина G;п
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
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