The invention relates to a tool holder (1) which is intended to receive a flexibly-deformable tool (12), such as an injection needle or a cutting tool. The operating direction (15) of the tool is not parallel to the axis (14) of the tool holder (1). The inventive tool holder (1) is characterised in that it ends in a part (4) of a channel that opens out onto the outside of the body (2) of the tool holder, comprising a surface having generatrices that are essentially parallel to the axis of the body and enabling the tool (12) to be introduced by moving same in relation to the axis (14) of the body of the tool holder. Said tool holder (1) comprises forms that enable the safe introduction of the needle, simple cleaning, inexpensive manufacture and a quality connection between the needle and the body.