WHITEMAN KATHLEEN R,OLEARY James J,LUTZ ROBERT JOHN
申请号：
IN6457/DELNP/2012
公开号：
IN2012DN06457A
申请日:
2012.07.20
申请国别(地区):
IN
年份:
2014
代理人:
摘要：
The present invention relates to surprisingly effective anti cancer drug combinations pharmaceutical compositions comprising the same and uses thereof in the treatment of ovarian cancer. In particular the present invention is based on the discovery that the administration of a CD56 antibody linked to a cytotoxic compound ( an immunoconjugate) in combination with at least two chemotherapeutic agents (in particular a taxane compound and a platinum compound) improves the therapeutic index in the treatment of ovarian cancer over and above the additive effects of the anticancer agents used alone. In one embodiment of the invention combinations of the CD56 antibody or fragment thereof linked to a cytotoxic compound plus additional chemotherapeutic agents have a synergistic effect in the ovarian cancer therapeutic index. The present invention also provides methods of modulating the growth of selected cell populations such as ovarian cancer cells by administering a therapeutically effective amount of such combinations.
