The present invention relates to a monolayer tablet for use in the treatment of tuberculosis comprising a mixture of: - granules comprising isoniazid, pyrazinamide, ethambutol or a pharmaceutically acceptable salt thereof and at least one granulation binder, - rifampicine in powder form, - extragranular excipients, wherein all of the granules have a particle size that is less than 0.599 mm, preferably less than 0.5 mm, more preferably less than 0.422 mm, and to its process of preparation.本發明係關於用於肺結核治療的單層錠劑，其包含以下之混合物：- 包含異菸鹼醯胺、吡醯胺、乙胺丁醇或其醫藥學上可接受之鹽以及至少一種造粒黏合劑的顆粒，- 粉末型態之利福平(rifampicine)，- 顆粒外賦形劑，其中，所有顆粒的粒度小於0.599mm，較佳小於0.5mm，更佳小於0.422mm，且關於其製備方法。
