Composition for control of statin side effect with extract of Pinellia ternata Atractylodes macrocephala Gastrodia elata Citrus unshiu peel Poria cocos Crataegus pinnatifida Siegesbeckia pubescens Makino and Coptis japonica Makino
NATIONAL DEVELOPMENT INSTITUTE OF KOREAN MEDICINE;한약진흥재단
发明人:
SEOK, YOUNG MI,석영미,SO, JAI HYUN,소재현,KANG, YUN HWAN,강윤환,SHIN, HEUNG MOOK,신흥묵,SEOK, YOUNG MIKR,SO, JAI HYUNKR,KANG, YUN HWANKR,SHIN, HEUNG MOOKKR
申请号：
KR1020160149209
公开号：
KR1020180052790A
申请日:
2016.11.10
申请国别(地区):
KR
年份:
2018
代理人:
摘要：
The present invention relates to a pharmaceutical composition including an extract of mixed medicinal herbs of Pinellia ternata Breit., Atractylodis Rhizoma alba, Gastrodia elata Blume, dried orange peel, larch agaric, fruits of Crataegus pinnatifida Bunge, Siegesbeckia pubescens Makino, and Coptis japonica Makino and, more specifically, relates to a composition to inhibit one or more selected among renal failure, angina, diabetes, hypertension, hepatotoxicity, and muscular disease, which are side effects induced by statin. According to the present invention, the composition includes an extract of mixed medicinal herb of Pinellia ternata Breit., Atractylodis Rhizoma alba, Gastrodia elata Blume, dried orange peel, larch agaric, fruits of Crataegus pinnatifida Bunge, Siegesbeckia pubescens Makino, and Coptis japonica Makino, thus increasing an amount of Coenzyme Q10, decreasing an amount of angiotensin and angiotensin converting enzyme (ACE), which are a hypertension related marker, and decreasing an amount of aspartate aminotransferase (AST) in blood, thereby providing an effect of inhibiting side effects of statin.본 발명은 반하(半夏), 백출(白朮), 천마(天麻), 진피(眞皮), 복령(茯笭), 산사(山査), 희렴 및 황련(黃蓮)을 혼합한 약재 추출물 포함하는 약품 조성물에 관한 것으로, 구체적으로는 스타틴으로 인한 부작용인 신부전, 협심증, 당뇨, 고혈압, 간독성, 근육병증 중 선택되는 하나 이상을 억제하는 조성물에 관한 것이다. 본 발명의 조성물은 반하, 백출, 천마, 진피, 복령, 산사, 희렴 및 황련을 혼합한 약재의 추출물을 포함함으로써, 혈액에서 코엔자임 Q10(Coenzyme Q10)의 양을 증가시키고, 고혈압 관련 마커인 안지오텐신(angiotensin)과 안지오텐신전환효소(angiotensin converting enzyme, ACE)의 양을 감소시키며, 간세포 효소(aspartate aminotransferase, AST)의 양을 감소시켜 스타틴의 부작용을 억제하는 효과를 발휘한다.
