FEY, GEORG H.,BRACIAK, TODD,ROSKOPF, CLAUDIA CHRISTINA,SCHUBERT, INGO,HOPFNER, KARL-PETER,FENN, NADJA,JACOB, UWE,WILDENHAIN, SARAH,WILDENHEIN, SARAH
申请号：
CA3045385
公开号：
CA3045385A1
申请日:
2017.12.01
申请国别(地区):
CA
年份:
2018
代理人:
摘要：
The present invention relates to a nucleic acid molecule encoding a single chain triplebody capable of specifically binding to CD33, CD16 and CD123, wherein said nucleic acid molecule comprises: (a) a nucleic acid molecule encoding a protein represented by SEQ ID NO:1； (b) a nucleic acid molecule represented by SEQ ID NO:2； (c) the nucleic acid molecule of (b), wherein each thymine is replaced by uracil； (d) a nucleic acid molecule encoding a protein having at least 98% sequence identity to the protein of (a)； or (e) a nucleic acid molecule that is degenerate with respect to the nucleic acid molecule of (b) or (c). The present invention further relates to a vector comprising the nucleic acid molecule of the invention, a host cell transformed or transfected with the nucleic acid molecule or the vector of the invention, as well as to a method for the production of a single chain triplebody capable of specifically binding to CD33, CD16 and CD123. Furthermore, the present invention also relates to a single chain triplebody capable of specifically binding to CD33, CD16 and CD123 encoded by the nucleic acid molecule of the invention, as well as to a composition comprising the nucleic acid molecule, the vector, the host cell and/or the single chain triplebody of the invention. Also encompassed by the present invention are the nucleic acid molecule, the vector, the single chain triplebody and/or the composition of the invention for use in the treatment of acute myeloid leukaemia and/or myelodysplastic syndrome, as well as a method of treating acute myeloid leukaemia and/or myelodysplastic syndrome.
