Michael E. Rickey,J. Michael Ramstack,Rajesh Kumar
申请号：
US12967757
公开号：
US08187672B2
申请日:
2010.12.14
申请国别(地区):
US
年份:
2012
代理人:
摘要：
Methods for preparing microparticles having reduced residual solvent levels. Microparticles are contacted with a non-aqueous washing system to reduce the level of residual solvent in the microparticles. Preferred non-aqueous washing systems include 100% ethanol and a blend of ethanol and heptane. A solvent blend of a hardening solvent and a washing solvent can be used to harden and wash microparticles in a single step, thereby eliminating the need for a post-hardening wash step.
