INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 20 September 2018 (20.09.2018) WIPO I PCT ill~~~~~~~~ 0111111010VIIIOH olo Oil 0111 oo0111IIIIIlII111111 OIIIIII (10) International Publication Number WO 2018/165707 Al (51) International Patent Classification: A61K 8/64 (2006.01) A61K 38/00 (2006.01) A61K 33/24 (2006.01) A61P 1/02 (2006.01) A61K 33/16 (2006.01) A61Q 11/00 (2006.01) A61K 8/21 (2006.01) (21) International Application Number: PCT/AU2018/050230 (22) International Filing Date: 14 March 2018 (14.03.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 2017900892 14 March 2017 (14.03.2017) AU (71) Applicant: THE UNIVERSITY OF MELBOURNE [AU/AU]； The University of Melbourne, The University Of Melbourne, Victoria 3010 (AU). (72) Inventor: REYNOLDS, Eric Charles； c/- The University of Melbourne, The University Of Melbourne, Victoria 3010 (AU). (74) Agent: FPA PATENT ATTORNEYS PTY LTD； Level 43, 101 Collins Street, Melbourne, Victoria 3000 (AU). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI
