ROBERT DR. FRANK,GREGOR DR. BAHRENBERG,THOMAS DR. CHRISTOPH,BERNHARD DR. LESCH,JEEWOO PROF. DR. LEE
申请号：
ARP120103518
公开号：
AR088003A1
申请日:
2012.09.25
申请国别(地区):
AR
年份:
2014
代理人:
摘要：
Amineptine was used as the binding agent of vanilloide receptor, as well as the pharmaceutical compounds containing these compounds, and these compounds were used for treatment and / or prevention of pain, disease and / or other disorders. 1. Claim 1: a general alternative compound (1),1. One of the wastes R1 and RZ is ch8322n-n (r831393) - S (= O) 832222-r1830404；R8313 stands for H, ch8323 or c83322； h8325；R83044 stands for nh832222,CH₃ or C₂H₅,The remaining residues of R1 and R2 were selected from a group consisting of H, F, Cl, Br, I and ch832323,-Oh, ch832222-ch832222 - Oh, ch832222-o-ch8323；-0-0-0CF8323,Oh, oc832323,O-CH₂-OH, O-CH₂-O-CH₃,O-C₂H₅,O-ch-832222-ch-832222-oh, o-ch-832222-ch-832223 and nh-832222；R3 was selected from a group consisting of H, F, Cl, Br, I and ch832323；CF8323,Oh, o-ch83323,O-CF₃,-NH832222；Z for n-r8308； 7495；Wherein r8308； 74955 represents h or ch8323；R8308； 7491 stands for H O c832233；R830909 represents h or ch8323；X for N or CH； r8310 for cf83231；an unsaturated, saturated C₁₋₄ aliphatic residue or a saturated, unsaturated C₃₋₆ cycloaliphatic residue； R⁷ represents H, or an unsubstituted C₁₋₄ aliphatic residue； R⁸ represents an aliphatic residue C₁₋₄,a. One, two or three replacements were not selected from the F, ll, Br, I, oh, o-ch8323 group to replace monkey, di or Tristan；O-CH₂-OH, O-CH₂-O-CH₃,O-C₂H₅,O-CH₂-CH₂-OH, O-CH₂-CH₂-O-CH₃,NH.8322；NH (CH)y N (CH)a cycloaliphatic residue C₃₋₆,optionally linked by a bridge via an unsubstituted, saturated, unsubstituted or mono- aliphatic group of C₁₋₄,Say...O one of the three independently elected replacement members, consisting of F, Cl, Br, I and ch832323；C₂H₅,-Oh, ch832222-ch832222 - Oh, ch832222-o-ch8323；-0-0-0CH -NH (CH)CH -N (CH)CF8323,Oh, o-ch83323,O-CH₂-OH, O-CH₂-O-CH₃,O-C₂H₅,O-CH₂-CH₂-OH, O-CH₂-CH₂-O-CH₃,NH.8322；NH (CH)y N (CH)aryl or heteroaryl, in each case optionally linked by a bridge via an unsubstituted, saturated C₁₋₄ aliphatic group, and in each case unsubstituted or mono-,O one
