THIS INVENTION RELATES TO ACRYSTALLINE FORM OF (10R)-7-AMINO-12-FLUORO- 2,10,16-TRIMETHYL- 5-OXO-10,15,16,17-TETRAHYDRO-2H-8,4-(METHENO)PYRAZOLO 4,3- H 2,5,11 BENZOXADIAZACYCLO- TETRADECINE-3-CARBONITRILE (LORLATINIB) FREE BASE (FORM 7). THIS INVENTION ALSO RELATES TO PHARMACEUTICAL COMPOSITIONS COMPRISING FORM 7, AND TO METHODS OF USING FORM 7 AND SUCH COMPOSITIONS IN THE TREATMENT OF ABNORMAL CELL GROWTH, SUCH AS CANCER, IN A MAMMAL.

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专利权人:

发明人:

BIRCH MELISSA J,PENCHEVA KLIMENTINA DIMITROVA

申请号：

IN201817005751

公开号：

IN201817005751A

申请日:

2018.02.15

申请国别(地区):

IN

年份:

2018

代理人:

摘要：

This invention relates to acrystalline form of (10R)-7-amino-12-fluoro-2,10,16-trimethyl- 5-oxo-10,15,16,17-tetrahydro-2H-8,4- (metheno)pyrazolo 4,3-h 2,5,11 benzoxadiazacyclo- tetradecine-3-carbonitrile (lorlatinib) free base (Form 7). This invention also relates to pharmaceutical compositions comprising Form 7, and to methods of using Form 7 and such compositions in the treatment of abnormal cell growth, such as cancer, in a mammal.

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