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Novel Sulfonic Acid-Containing Thyromimetics, and Methods for Their Use
专利权人:
Scott J. Hecker;Serge H. Boyer;Mali Venkat Reddy
发明人:
Serge H. Boyer,Scott J. Hecker,Mali Venkat Reddy
申请号:
US13148709
公开号:
US20120046364A1
申请日:
2010.02.09
申请国别(地区):
US
年份:
2012
代理人:
摘要:
The present invention relates to sulfonic acid containing compounds of formula IB, in which G, R1, R3 and T are as defined in the claims, that bind to thyroid receptors in the liver. Activation of these receptors results in modulation of gene expression of genes regulated by thyroid hormones. The compounds can be used to treat diseases and disorders including metabolic diseases such as obesity, NASH, hypercholesterolemia and hyperlipidemia, as well as associated conditions such as atherosclerosis, coronary heart disease, impaired glucose tolerance, metabolic syndrome X and diabetes.
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