VENKATESH, GOPI M.,QIAN, KEN KANGYI,VANGALA, SHYAM,CLEVENGER, JAMES M.,GUENTHER, DONALD
申请号：
CA2563440
公开号：
CA2563440C
申请日:
2005.03.31
申请国别(地区):
CA
年份:
2012
代理人:
摘要：
A tablet that rapidly disintegrates in the oral cavity comprising a compressedblend of rapidly dispersing microgranules prepared by granulating a sugaralcohol or a saccharide or a mixture thereof having an average particle sizeless than about 30 microns and a disintegrant, and a taste-masked microcapsulecontaining at least one drug, the microcapsule being prepared by granulating apharmaceutically acceptable formulation comprising at least one drug in atherapeutically effective amount and at least one polymeric binder thatimproves resilience of the microgranules, wet milling the granulated mass, andmicroencapsulating the milled granules to provide microcapsules.
