Scott Webster Ballinger,Danny R. Welch,Robert Allen Kesterson,Larry W. Johnson
申请号：
US14697243
公开号：
US20150231278A1
申请日:
2015.04.27
申请国别(地区):
US
年份:
2015
代理人:
摘要：
Provided herein are mitochondrial-nuclear exchanged cells and animals comprising mitochondrial DNA (mtDNA) from one subject and nuclear DNA (nDNA) from a different subject. Methods for producing a mitochondrial-nuclear exchanged animal and animals made by the methods are provided. Also provided are methods of screening for agents useful for treating a disease or disorder using mitochondrial-nuclear exchanged animals or cells, tissues or organs thereof.
