ВЕРМА Дая (US),ТЭН Ю (Хелен) (US),СИНГХ Раджиндер (US),ТОМПСОН Дан (US)
申请号：
RU2011135424/15
公开号：
RU2011135424A
申请日:
2010.01.28
申请国别(地区):
RU
年份:
2013
代理人:
摘要：
1. A pharmaceutical formulation containing (a) (R) -2-amino-7- [4-fluoro-2- (6-methoxypyridin-2-yl) phenyl] -4-methyl-7,8-dihydro-6H -pyrido [4,3-d] pyrimidin-5-one or a pharmaceutically acceptable salt thereof； and at least one of the following additives: (b) a surfactant, or (c) an acid, wherein the pharmaceutical formulation is a solid oral dosage form and (R) -2-amino-7- [4-fluoro-2 - (6-methoxypyridin-2-yl) phenyl] -4-methyl-7,8-dihydro-6H-pyrido [4,3-d] pyrimidin-5-one, or its salt may be in the form of small particles with a median particle size from about 10 nm to about 40 microns, provided that if the surfactant is vitamin E in the form of TPGS, then it is obtained by direct mixing. The pharmaceutical formulation of claim 1, wherein the surfactant is vitamin E in the form of TPGS, polysorbate 80, polysorbate 20, sodium lauryl sulfate, an anionic surfactant such as alkyl sulfate, i.e. sodium, potassium n-dodecyl sulfate, magnesium n-dodecyl sulfate, n-tetradecyl sulfate, n-hexadecyl sulfate or n-octadecyl sulfate, such as alkyl ether sulfate, i.e. sodium n-dodecyloxyethyl sulfate, potassium n-dodecyloxyethyl sulfate, magnesium n-dodecyloxyethyl sulfate, n-tetradecyloethyl sulfate, n-hexadecyloxyethyl sulfate, n-octadecyloxyethyl sulfate, such as alkanesulfonate, i.e. sodium n-dodecane sulfonate, potassium n-dodecane sulfonate, magnesium n-dodecane sulfonate, n-tetradecane sulfonate, n-hexadecane sulfonate, n-octadecane sulfonate, a nonionic surfactant such as fatty acid esters and polyhydroxy alcohols, i.e. sorbitan monolaurate, sorbitol1. Фармацевтическая препаративная форма, содержащая(а) (R)-2-амино-7-[4-фтор-2-(6-метоксипиридин-2-ил)фенил]-4-метил-7,8-дигидро-6H-пиридо[4,3-d]пиримидин-5-он или его фармацевтически приемлемую соль； и по меньшей мере одну из следующих добавок:(б) поверхностно-активное вещество, или(в) кислоту,где фармацевтическая препаративная форма представляет собой твердую оральную лекарственную форму и (R)-2-амино-7-[4-фтор-2-(6-метокси
