A system for preventing recurrence of diverticulitis includes a semi-permeable sleeve configured to be placed within a colonic lumen relative to one or more diverticulum lining the colonic lumen. The system also includes at least first and second collars disposed on opposing ends of the semi-permeable sleeve. The collars are configured to be selectively expanded radially outward to anchor the semi-permeable sleeve within the colonic lumen. The semi-permeable sleeve is configured to prevent permeation of undesirable material from within the colonic lumen into the at least one diverticulum and allow permeation of desirable material from the exterior of the semi-permeable sleeve into the colonic lumen.
