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PERORAL ACTIVE AGENT SUSPENSION
专利权人:
BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG
发明人:
TUERCK, DIETRICH,SCHMELMER, VEIT
申请号:
HU0102036
公开号:
HU228474B1
申请日:
1999.03.23
申请国别(地区):
HU
年份:
2013
代理人:
摘要:
Orally administrable suspension of a non-steroidal antiinflammatory drug (NSAID) in a physiologically inert dispersion medium in which the solubility of the NSAID is low, so that the suspension has no detectable inherent taste, contains (a) a small amount of finely divided silica, which is added the dispersion medium under high shear conditions to form a suspension-stabilizing 3-dimensional solid structure, and (b) a small amount of a soluble hydrophilic polymer. An Independent claim is also included for the production of an orally administrable liquid NSAID formulation in the form of a stabilized suspension by (i) grinding the NSAID so that at least 90% of the particles are smaller than 50 mu m, (ii) suspending the ground NSAID in a physiologically inert dispersion medium in which the solubility of the NSAID is low, (iii) adding a small amount of finely divided silica under high shear conditions, (iv) adding a small amount of a soluble hydrophilic polymer, and (v) adding one or more flavors, sweeteners, excipients and/or preservatives.
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