The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of Hemoglobin (HBF/HBG), in particular, by targeting natural antisense polynucleotides of Hemoglobin (HBF/HBG). The invention also relates to the identification of these antisense oligonucleotides and their use in treating diseases and disorders associated with the expression of HBF/HBG.L'invention porte sur des composés antisens qui modulent l'expression et/ou la fonction de gènes de globine. Les procédés de traitement de maladies associées aux globines comprennent l'administration d'un ou de plusieurs composés antisens à des patients.