Novel octahydro thieno quinoline, the pharmaceutical composition comprising the derivative and their purposes

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专利权人:

橘生药品工业株式会社;橘生藥品工業株式會社; LTD.;KISSEI PHARMACEUTICAL CO.;KISSEI PHARMACEUTICAL CO., LTD.

发明人:

Toshihiro NISHIMURA,西村俊洋,Hirotaka TERANISHI,寺西弘孝,Masako YOSHIDA,吉田正子,Yasunori UENO,上野康德,Kiyoshi KASAI,河西洁,河西潔

申请号：

MOJ001998

公开号：

MOJ001998B

申请日:

2015.12.29

申请国别(地区):

MO

年份:

2016

代理人:

摘要：

The present invention provides the compound or its pharmaceutically acceptable salt of the d2 dopamine receptor stimulating activity of display strength indicated by leading to formula (I): wherein R1 is cyano etc.； R2 and R3 is hydrogen atom etc.； R4 is C1-6 alkyl etc.； R5 is C1-6 alkyl, halogenated C1-6 alkyl, naphthenic base, naphthenic base C1-6 alkyl, aralkyl etc.； R6 and R7 is respectively hydrogen, C1-6 alkyl, halogenated C1-6 alkyl, naphthenic base, C1-6 alkoxy C 1-6 alkyl, R12R13N-C1-6 alkyl etc.. The present invention also provides the medical composition and its uses comprising the compound.本發明提供顯示强力的多巴胺D2受體刺激活性的由通式(I)表示的化合物或其藥學上可接受的鹽：其中R1爲氰基等；R2和R3爲氫原子等；R4爲C1-6烷基等；R5爲C1-6烷基、鹵代C1-6烷基、環烷基、環烷基C1-6烷基、芳烷基等；R6和R7各自爲氫、C1-6烷基、鹵代C1-6烷基、環烷基、C1-6烷氧基C1-6烷基、R12R13N-C1-6烷基等。本發明還提供包含所述化合物的藥物組合物及其用途。

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