MEDIZINISCHE UNIVERSITÄT WIEN;UNIVERSITÄTSKLINIKUM FREIBURG
发明人:
GRUBER, Christian Werner,GRUENDEMANN, Carsten
申请号：
EPEP2012/076739
公开号：
WO2013/093045A3
申请日:
2012.12.21
申请国别(地区):
EP
年份:
2013
代理人:
摘要：
The present invention relates to a pharmaceutical composition comprising a cyclotide for use in immune suppression as well as to a method for immune suppression comprising the step of administering an effective amount of a pharmaceutical composition comprising such a cyclotide to a subject in need thereof. The present invention also relates to a pharmaceutical composition comprising a cyclotide for use in treating or preventing a disorder selected from the group consisting of (i) an autoimmune disorder； (ii) a hypersensitivity disorder； and (iii) a lymphocyte-mediated inflammation. Likewise, the present invention also relates to a method for treating or preventing a disorder selected from the group consisting of (i) an autoimmune disorder； (ii) a hypersensitivity disorder； and (iii) a lymphocyte-mediated inflammation. The present invention further relates to a method of screening for and/or selecting an immunosuppressive cyclotide or a mutation which results in a mutated cyclotide having an induced or enhanced immunosupressive activity. The present invention further relates to a method of producing an immunosuppressive cyclotide or an immunosuppressive pharmaceutical composition. The present invention further relates to a mutated cyclotide having immunosuppressive activity and a pharmaceutical composition comprising the same.La présente invention concerne une composition pharmaceutique comprenant un cyclotide pour utilisation dans l'immunosuppression ainsi qu'un procédé pour l'immunosuppression comprenant l'étape d'administration d'une quantité efficace d'une composition pharmaceutique comprenant un tel cyclotide à un sujet nécessitant celui-ci. La présente invention concerne en outre une composition pharmaceutique comprenant un cyclotide pour utilisation dans le traitement ou la prévention d'un trouble choisi dans le groupe constitué de (i) un trouble auto-immun ； (ii) un trouble d'hypersensibilité ； et (iii) une inflammation médiée par les lymphocytes. De manière
