The present invention relates to a novel musculoskeletal stem cell (MSSC) differentiated from an embryonic stem cell (ESC) or an induced pluripotent stem cell (iPSC). The musculoskeletal stem cell of the present invention can be easily derived from human embryonic stem cells or human induced pluripotent stem cells and effectively differentiated into cartilage, tendons, and muscles as well as bones, thus finding useful applications in the prevention or treatment of various musculoskeletal diseases.La présente invention concerne une nouvelle cellule souche musculo-squelettique (MSSC) différenciée à partir d'une cellule souche embryonnaire (ESC) ou d'une cellule souche pluripotente induite (iPSC). La cellule souche musculo-squelettique de la présente invention peut être facilement dérivée de cellules souches embryonnaires humaines ou de cellules souches pluripotentes induites humaines et efficacement différenciée en cartilage, tendons et muscles ainsi qu'en os, trouvant ainsi des applications utiles dans la prévention ou le traitement de diverses maladies musculo-squelettiques.본 발명은 ESC(embryonic stem cell) 또는 iPSC(induced pluripotent stem cell)로부터 분화된 신규한 근골격계 줄기세포(MSSC, musculoskeletal stem cell)에 관한 것이다. 본 발명의 근골격계 줄기세포는 인간배아줄기세포 또는 인간유도만능줄기세포로부터 손쉽게 유도될 수 있으며, 골 뿐만 아니라 연골, 건, 근육으로 효과적으로 분화되어, 다양한 근골격계 질환의 예방 또는 치료에 유용하게 사용될 수 있다.