EKTA SETH CHHABRA,HAIYAN JIANG,ROBERT PETERS,TONGYAO LIU
申请号：
BR112014017165
公开号：
BR112014017165A2
申请日:
2013.01.12
申请国别(地区):
BR
年份:
2017
代理人:
摘要：
abstract the present invention provides a vwf fragment comprising the domain and d3 domain of vwf, a chimeric protein comprising the vwf fragment and a heterologous moiety, or a chimeric protein comprising the vwf fragment and a fviii protein and methods of using the same. a polypeptide chain comprising a vwf fragment of the invention binds to or is associated with a polypeptide chain comprising a fviii protein and the polypeptide chain comprising the vwf fragment can prevent or inhibit binding of endogenous vwf to the fviii protein. by preventing or inhibiting binding of endogenous vwf to the fviii, which is a half-life limiting factor for fviii, the vwf fragment can induce extension of half-life of the fviii protein. The invention also includes nucleotides, vectors, host cells, methods of using the vwf fragment, or the chimeric proteins. _________________________ translation of abstract patent summary: "chimeric factor viii polypeptides and their uses". The present invention provides a vwf fragment comprising the vwf d 'and domain d3 domain, a chimeric protein comprising the vwf fragment and a heterologous moiety or a chimeric protein comprising the vwf fragment and a fviii protein and methods of use thereof. A polypeptide chain comprising a vwf fragment of the invention binds to or is associated with a polypeptide chain comprising a fviii protein, and the polypeptide chain comprising the vwf fragment may prevent or inhibit binding of endogenous vwf to the fviii protein. By preventing and inhibiting endogenous vwf binding to fviii, which is a limiting factor for fviii half-life, the vwf fragment can induce fviii half-life strain. The invention also includes nucleotides, vectors, host cells, methods of using the vwf fragment or the chimeric proteins.abstract the present invention provides a vwf fragment comprising the d' domain and d3 domain of vwf, a chimeric protein comprising the vwf fragment and a heterologous moiety, or a chimeric protein comprising the vwf fr
