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Method of Treating Pulmonary Hypertension by Administration of Natriuretic Peptide Receptor C Signaling Pathway Activators
专利权人:
Emmanuel E EGOM
发明人:
Emmanuel E EGOM
申请号:
US15530196
公开号:
US20180318397A1
申请日:
2015.05.01
申请国别(地区):
US
年份:
2018
代理人:
摘要:
The present invention is based upon the observation that inhibition of NPR-C Signaling pathway leads to the development of pulmonary arterial hypertension (PAH). Accordingly, the invention provides a mouse model for PAH, and proposes a method of using synthetic analogs of the NPR-C signaling pathway, specifically synthetic C-type atrial natriuretic factor or intermediates for, or modulators of, the NPR-C signaling pathway as anti-pulmonary vasculopathy agents. Activators of the NPR-C signaling pathway are disclosed to treat or prevent vasculopathy, including but not limited to PAH and other types of pulmonary hypertension, peripheral vascular disease, critical limb ischemia, coronary artery disease, and diabetic vasculopathy.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
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