POLYPEPTIDE DE FUSION CONSTITUÉ D'UN POLYPEPTIDE ANTI-INFLAMMATOIRE ET D'UN FRAGMENT DE MONOMÈRE DE FERRITINE LIÉS PAR FUSION ET COMPOSITION PHARMACEUTIQUE DESTINÉE À PRÉVENIR ET À TRAITER LES MALADIES INFLAMMATOIRES LE CONTENANT À TITRE DE PRINCIPE ACTIF
Kyungpook National University Industry-Academic Cooperation Foundation;Korea Institute of Science and Technology
发明人:
BAE, Jong-Sup,KIM, In-San,LEE, Won Hwa,SEO, Jun Young,KIM, So Youn
申请号：
EP16842349
公开号：
EP3345929A4
申请日:
2016.09.02
申请国别(地区):
EP
年份:
2019
代理人:
摘要：
The present invention relates to: a fusion polypeptide in which an anti-inflammatory polypeptide and a ferritin monomer fragment are bound； and a pharmaceutical composition for treating inflammatory diseases, containing the same as an active ingredient and, more specifically, to: a fusion polypeptide in which an anti-inflammatory polypeptide is fused to an N-terminus and/or a C-terminus of a ferritin monomer fragment from which a portion of a fourth loop and a fifth helix, of a human derived ferritin monomer, are removed； and a use thereof for treating inflammatory diseases. As in the above, the fusion polypeptide, which has an amino acid sequence represented by SEQ ID NO: 1 and in which an anti-inflammatory polypeptide is fused to an N-terminus and/or a C-terminus of a fragment of a human-derived ferritin monomer, can fuse two types of anti-inflammatory polypeptides, acting through different mechanisms, into a nano cage and administer the same, and thus the fusion polypeptide can exhibit an excellent effect in the treatment of inflammatory diseases including sepsis.
