An administration set is configured to couple to a control module of a peristaltic infusion pump. The set can include a pressure plate and a peristaltic tube. The pressure plate can have attachment features structured to mate with corresponding attachment features of the control module such that the pressure plate is maintained in a fixed position relative to the control module. The peristaltic tube can include a first portion having first inner and outer diameters, a second portion downstream of the first portion having second inner and outer diameters, and a transition portion between the first and second portions. The peristaltic tube can be located along the pressure plate and positioned such that when the attachment features of the pressure plate and control module are mated, an expulsor of the control module engages the first portion and an air-in-line detector of the control module engages the second portion.
