SEL DE FUMARATE DE L'UREE (R)-3-(1-(2,3-DICHLORO-4-(PYRAZIN-2-YL)PHENYL)-2,2,2-TRIFLUOROETHYL)-1-METHYL-1-(1-METHYLPIPERIDIN-4-YL), PROCEDES DE PREPARATION ET UTILISATIONS DE CELUI-CI

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专利权人:

HELSINN HEALTHCARE SA

发明人:

GARCIA RUBIO, SILVINA,PERSEGHINI, MAURO,GUAINAZZI, ANGELO,PIETRA, CLAUDIO,GIULIANO, CLAUDIO,GUILIANO, CLAUDIO

申请号：

CA3083509

公开号：

CA3083509A1

申请日:

2018.12.07

申请国别(地区):

CA

年份:

2019

代理人:

摘要：

Provided are various embodiments relating to fumarate salt of (R)-3-(1-(2,3-dichloro-4-(pyrazin-2-yl)phenyl)-2,2,2-trifluoroethyl)-1-methyl-1-(1-methylpiperidin-4-yl) urea, and methods of producing and using the same to treat conditions and disorders associated with an increase of ghrelin level, such as food abuse, alcohol addiction, and other disorders (e.g., Prader-Willi syndrome). Also provided are various embodiments relating to crystalline HM04 free base, different crystalline forms of HM04 fumarate salt, and methods of producing the same.

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