The present disclosure provides a connector preventing use and mechanical engagement with an I.V. luer catheter having luer compatible fittings. The connector comprises a body portion having a non-luer compatible distal patient access fitting, a non-luer compatible proximal fluid delivery device fitting, and a non-luer syringe port positioned between the distal and proximal non-luer compatible fittings. In some embodiments, the syringe port incorporates a normally closed to atmosphere valve accessible by a non-luer syringe for administration of fluid and medications.