Phosphorylation on the Thr-248 and/or Thr-250 residues of transcription factor E2F4 as a therapeutic target in pathological processes associated with somatic polyploidy
CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS (CSIC)
发明人:
Jose Maria Frade Lopez
申请号：
US14352584
公开号：
US09567384B2
申请日:
2012.11.15
申请国别(地区):
US
年份:
2017
代理人:
摘要：
The object of the invention is based on inhibiting specific phosphorylation on Thr248 and/or Thr250 residues of human transcription factor E2F4 to inhibit somatic endoreduplication processes in postmitotic cells which may be associated with various pathological conditions. The invention covers all currently known methods for the specific inhibition of protein phosphorylation (including the expression of mutant forms of E2F4 without Thr residues phosphorylated by p38MAPK) or methods developed in the future that may be applied to Thr-248 and/or Thr-250 residues of human transcription factor E2F4.
