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PHOSPHODIESTERASE ACTIVITY AND REGULATION OF PHOSPHODIESTERASE 1B-MEDIATED SIGNALING IN BRAIN
专利权人:
Paul Greengard;David Repaske;Gretchen Snyder
发明人:
Paul Greengard,David Repaske,Gretchen Snyder
申请号:
US12951775
公开号:
US20130239234A1
申请日:
2010.11.22
申请国别(地区):
US
年份:
2013
代理人:
摘要:
The present invention provides methods and compositions for modulating the activity of phosphodiesterase 1B (PDE1B) in intracellular signaling pathways, including but not limited to, dopamine D1 intracellular signaling pathways. The invention also provides methods and compositions for modulating the activities of intracellular signaling molecules, including, but not limited to, DARPP-32 and GluR1 AMPA receptor, via modulation of PDE1B. The invention also provides pharmaceutical compositions and methods of screening for compounds that modulate PDE1B activity. The invention also provides methods of treating or ameliorating the symptoms of a disorder, including but not limited to a PDE1B-related disorder or a dopamine D1 receptor intracellular signaling pathway disorder, by administering a modulator of PDE1B, preferably, but not limited to, an inhibitor of PDE1B or an agent that decreases the production of PDE1B.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
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