The disclosure relates to a diazepine derivative represented by general formula (I), wherein the variables R1 and R2 are a hydrogen atom, etc. or R1 and R2 together with a benzene ring to which they are attached are a naphthalene ring, etc.； R3 and R4 are a hydrogen atom, etc.； R5 is a hydrogen atom, etc.； R6 and R7 are a hydrogen atom, etc.； X is C, CH or N and Y is N, NH or C (=O), provided that when X is N, Y is not N or NH and when X is C or CH, Y is not C (=O)； Z is an oxygen atom or a sulfur atom； A is a benzene ring, etc.； B is NHC (=O), etc.； D is an atomic bonding, etc.； E is an atomic bonding, etc.； G is benzene which may by substituted, etc.； and m is an integer of 0 to 5.) or a pharmaceutically acceptable salt thereof, and a P2X4 receptor antagonist.
