ヘプシジンによる鉄代謝を制御するためのTGF-βスーパーファミリーの化合物の調節因子の使用

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专利权人:

ザ ジェネラル ホスピタル コーポレイション

发明人:

リン ハーバート ワイ.,バビット ジョディー,チュン レイモンド ティー.,サマド タレク エー.,シュネイヤー アラン エル.,ウルフ クリフォード

申请号：

JP2007556264

公开号：

JP5063366B2

申请日:

2006.02.16

申请国别(地区):

JP

年份:

2012

代理人:

摘要：

The present invention provides new systems and strategies for the regulation of iron metabolism in mammals. In particular, methods of using agonists and antagonists of TGF-² superfamily members to modulate the expression or activity of hepcidin, a key regulator of iron metabolism, are described. The inventive methods find applications in the treatment of diseases associated with iron overload, such as juvenile hemochromatosis and adult hemochromatosis, and in the treatment of diseases associated with iron deficiency, such as anemia of chronic disease and EPO resistant anemia in end-stage of renal disease. The present invention also relates to screening tools and methods for the development of novel drugs and therapies for treating iron metabolism disorders.

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中国工程科技知识中心

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