The invention relates to the technical field of Chinese medicine preparations, and in particular relates to a chrysanthemum wall-broken preparation. The chrysanthemum wall-broken preparation is prepared as follows: crushing chrysanthemum into super-fine powder, then granulating by use of an ethanol-water wet method, extruding for forming at a certain rotating speed and drying, and the prepared chrysanthemum wall-broken preparation is high in bioavailability, strong in stability, and good in disintegration.