An isolated and purified hemorrhagic feline calicivirus FCV-DDl, wherein the strain has ATCC Patent Deposit Designation PTA-6204 or a viral clone derived therefrom. A vaccine according to Claim 4, wherein the additional feline calicivirus is selected from the group consisting of FCV-255, FCV-2280, FCV-Diva, FCV-Kaos, FCV- Bellingham, FCV20 F9, FCV-F4, FCV-M8 and a combination thereof. A method of protecting a feline against infection or preventing disease caused by feline calicivirus, Chlamydophila felis, feline leukemia virus, feline panleukopenia virus, feline rhinotracheitis virus, feline immunodeficiency virus, rabies virus, feline infectious peritonitis virus, Bartonella or a combination thereof which comprises administering to the feline an immunologically effective amount of the vaccine
