LEE, Yun Mi,이윤미,LEE, Young Seop,이영섭,KIM, Jin Sook,김진숙,KIM, Jung Hyun,김정현,KIM, Young Sook,김영숙,SHON, Eun Jin,손은진,KIM, Ki Mo,김기모,KIM, Ohn Soon,김온순,JUNG, Dong Ho,정동호,KIM, Chan-Sik,김찬식
申请号：
KRKR2011/005968
公开号：
WO2012/021038A3
申请日:
2011.08.12
申请国别(地区):
WO
年份:
2012
代理人:
摘要：
The present invention relates to a composition for preventing and treating diabetes complications including Speceria ramalana extract or fractions thereof as an active ingredient, and more particularly, to Spenceria ramalana extract or fractions thereof, which suppresses the generation of an advanced glycation end product, which is an indicator of diabetes complications, suppresses the activity of aldose reductase, and shows effective and significant prevention and treatment of diabetic retinopathy, thereby rendering the present invention useful as the active ingredient in the composition for preventing and treating various diabetes complications including diabetic retinopathy.La présente invention concerne une composition pour prévenir et traiter les complications du diabète comprenant un extrait de Spenceria ramalana ou des fractions de celui-ci en tant que substance active, et plus particulièrement, un extrait de Spenceria ramalana ou des fractions de celui-ci, qui supprime la génération dun produit final de glycation avancée, qui est un indicateur de complications du diabète, supprime lactivité de laldose réductase, et produit une prévention et un traitement efficaces et significatifs de la rétinopathie diabétique, de manière à rendre la présente invention utile en tant que substance active dans la composition pour prévenir et traiter différentes complications du comprenant la rétinopathie diabétique.본 발명은 마제황(Spenceria ramalana) 추출물 또는 이의 분획물을 유효성분으로 함유하는 당뇨합병증 예방 및 치료용 조성물에 관한 것으로서, 더욱 구체적으로는, 마제황 추출물 또는 이의 분획물은 당뇨합병증의 지표인 최종당화산물의 생성 및 알도즈 환원효소의 활성을 억제하고, 당뇨병성 망막증에 대한 유의적인 예방 및 치료효과를 나타내므로, 당뇨병성 망막증을 포함하는 다양한 당뇨합병증 예방 및 치료용 조성물의 유효성분으로서 유용하게 이용될 수 있다.
