包含抗‐NRP2抗體之組合物及方法农业专利-农业专业知识服务系统

发明人:: BURMAN, LUKE,波曼　路克,CHONG, YEE TING,张　宇婷,張　宇婷,GENG, YANYAN,耿艳艳,耿艷艷,GREENE, LESLIE NANGLE,格林　雷斯里　南葛,HAMEL, KRISTINA,汉默尔　克里斯汀娜,漢默爾　克里斯汀娜,KING, DAVID,金　大卫,金　大衛,MENEFEE, ANN,孟恩菲　安,RAU

摘要：: Provided are antibodies and antigen-binding fragments thereof that specifically bind to human neuropilin-2 (NRP2) polypeptides, including those that modulate binding interactions between human NRP2 and at least one NRP2 ligand, for example, human histidyl-tRNA synthetase (HRS), and which thereby modulate subsequent NRP2-mediated downstream signaling events, including related therapeutic compositions and methods for modulating NRP2 activity and treating diseases such as NRP2-associated diseases.本發明提供特異性結合於人類神經纖毛蛋白-2 (NRP2)多肽之抗體及其抗原結合片段，其包括調節人類NRP2與至少一種NRP2配體(例如人類組胺醯基-tRNA合成酶(HRS))之間的結合相互作用且進而調節後續經NRP2介導之下游信號傳導事件的彼等、包括用於調節NRP2活性及治療諸如NRP2相關疾病之疾病的相關治療組合物及方法。