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Phosphaplatins and their use in the treatment of cancers resistant to cisplatin and carboplatin
专利权人:
Rathindra N. Bose
发明人:
Rathindra N. Bose
申请号:
US13221458
公开号:
US08445710B2
申请日:
2011.08.30
申请国别(地区):
US
年份:
2013
代理人:
摘要:
The present invention provides phosphaplatins, stable isolated monomeric phosphato complexes of platinum (II) and (IV), and methods of use thereof for treating cancers, including cisplatin- and carboplatin-resistant cancers. Unlike cisplatin, these complexes do not readily undergo hydrolysis and are quite soluble and stable in aqueous solutions. Moreover, these complexes—unlike cisplatin, carboplatin, and related platinum-based anti-cancer agents—do not bind DNA. Rather, data suggests that phosphaplatins trigger overexpression of fas and fas-related transcription factors and some proapoptotic genes such as Bak and Bax. Nevertheless, the complexes exhibit tremendous cytotoxicity towards cancer cells. Thus, the present invention provides novel platinum anticancer agents that have a different molecular target than those in the art.
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中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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