The Trustees of the Stevens Institute of Technology
发明人:
Xiaojun Yu,Munish B. Shah,Wei Chang
申请号：
US16448550
公开号：
US20190328393A1
申请日:
2019.06.21
申请国别(地区):
US
年份:
2019
代理人:
摘要：
A nerve guidance conduit includes one or more guidance channels formed as porous polymeric structures. The guidance channels are within an outer tubular structure that includes randomly-oriented nanofibers. The guidance channels may have electrospun nanofibers on their inner and outer surfaces in a parallel alignment with the guidance channels. Such aligned nanofibers may also be present on the inner surface of the outer tubular structure. The outer surfaces of the guidance channels and the inner surface of the tubular structure define additional guidance channels. Such a nerve guidance conduit provides augmented surface areas for providing directional guidance and enhancing peripheral nerve regeneration. The structure also has the mechanical and nutrient transport requirements required over long regeneration periods.
