CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE;INSTITUT PASTEUR
发明人:
Christophe Prehaud,Monique Lafon,Pierre Lafaye
申请号：
US15508486
公开号：
US10640552B2
申请日:
2015.09.09
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The invention is in the domain of delivery of molecules to brain cells across the blood-brain barrier. The invention relates to a novel polypeptide-based carrier that allows the efficient delivery of an effector peptide, to neuron cells across the blood-brain barrier, and to methods for the production and testing of such carrier, including a model for testing the capacity of such molecule to cross the blood-brain barrier and/or the toxicity of molecules on the blood brain barrier and/or the capacity of molecules that have crossed to target human brain cells (e.g. neurons, astrocytes and microglial cells).
