abstract: the present invention relates to the field of medicinal chemistry, and in particular relates to 4- (five-membered heterocyclic pyrimidine / pyridine substituted) amino-1h-3-pyrazolecarboxamide derivatives, the preparation method thereof, pharmaceutical compositions containing these compounds and the medicinal use thereof, especially as protein kinase inhibitors for anti-tumor use. patent inhibitor of polycyclic substituted pyrazole kinase activity and its use. The present invention relates to the field of medicinal chemistry, and in particular to the substituted 5- (4- membered heterocyclic pyrimidine / pyridine) amino-1h-3-pyrazolecarboxamide derivatives, their method of preparation, pharmaceutical compositions containing these compounds and their medicinal use, especially as protein kinase inhibitors for anti-tumor use.abstract: the present invention relates to the field of medicinal chemistry, and in particular relates to 4-(five-membered heterocyclic pyrimidine/pyridine substituted) amino-1h-3-pyrazolecarboxamide derivatives, the preparation method thereof, pharmaceutical compositions containing these compounds and the medicinal use thereof, especially as protein kinase inhibitors for anti-tumour use. tradução do resumo resumo patente de invenção: "inibidores da atividade de pirazol cinase substituídos por policíclicos e seu uso". a presente invenção refere-se ao campo de química medicinal, e em particular refere-se aos derivados de 4-(pirimidina/piridina heterocíclica de cinco membros substituída) amino-1h-3-pirazolcarboxamida, ao seu método de preparação, às composições farmacêuticas contendo estes compostos e ao seu uso medicinal, especialmente como inibidores da proteína cinase para uso anti-tumoral.
