SMITH, Graham,BURNS, Aaron Craig,COLLINS, Michael Raymond,GREASLEY, Samantha Elizabeth,KANIA, Robert Steven,HOFFMAN, Robert Louis,HUANG, Qinhua,KUNG, Pei-Pei,LINTON, Maria Angelica,NARASIMHAN, Lakshmi
申请号：
PE2016002145
公开号：
PE20161436A1
申请日:
2015.04.17
申请国别(地区):
PE
年份:
2017
代理人:
摘要：
It refers to a compound with formula I: A and D are heterocompounds with optional substitution of 5 or 6 members； L is optional substitution - (cyclopropyl compound c4-c10)； R1 and R2 are hydrogen, C1-C4 tar, etc.； R3, R4, R5 and R6 are hydrogen, halogen, etc.； X and 0 or 1. Four four four four four four four four four four four four four four four four four four four four four four four four four four four four four four four four four four four four four four two-il] acetamide,There are others He also mentioned a pharmacology composer and a pharmacology portfolio. These compounds are useful for the treatment of abnormal cell growthSe refiere a un compuesto de formula I, donde: A y D son heteroarilo de 5 o 6 miembros opcionalmente sustituido； L es –(cicloalquilo C4-C10) opcionalmente sustituido； R1 y R2 son hidrogeno, alquilo C1-C4, entre otros； R3, R4, R5 y R6 son hidrogeno, halogeno, entre otros； x e y son 0 o 1. Son compuestos preferidos: 2-(piridin-2-il)-N-(5-{[(1S,3R)-3-{5-[(piridin-2-ilacetil)amino]-1,3,4-tiadiazol-2-il}ciclopentil]metil}-1,3,4-tiadiazol-2-il)acetamida, N-(5-{[(1R,3S)-3-[5-(acetilamino)-1,3,4-tiadiazol-2-il]ciclopentil}metil)-1,3,4-tiadiazol-2-il]acetamida, entre otros. Tambien se refiere a una composicion farmaceutica y a una combinacion farmaceutica. Dichos compuestos son utiles en el tratamiento del crecimiento celular anormal
