Cummings, W. Jason,Gray, Patrick,Tjoelker, Larry W.,Yabuki, Munehisa
申请号：
AU2014229020
公开号：
AU2014229020A1
申请日:
2014.03.14
申请国别(地区):
AU
年份:
2015
代理人:
摘要：
In one aspect, the invention provides an isolated antibody, or antigen-binding fragment thereof, comprising a bioactive peptide amino acid sequence, wherein the bioactive peptide amino acid sequence is an inhibitor of the complement system and is fused to at least one of: (i) the amino terminal region of at least one of: a light chain variable region and/or a heavy chain variable region； or (ii) the carboxy terminal region of at least one of: a light chain constant region and/or a heavy chain constant region, wherein the antibody inhibits complement activation.
