The present invention provides a hydrazide compound, which has a structure a shown in formula (I), for working as an inhibitor to blood coagulation factor Xa. The hydrazide compound or its salt can be used as a blood coagulation inhibitor for curing and preventing thrombus-disorders-related disease. The present invention provides an improved inhibitor to coagulation factor Xa via improving selectivity of the inhibitor to the factor Xa inorder to satisfied actial medical needs for a strong and efficient coagulation inhibitor.本發明提供一種作為凝血因子Xa抑制劑的醯肼類化合物,具有如下化學式(I)所示之結構。該化合物或其鹽類可以作為治療和預防血栓異常疾病的抗凝劑,本發明通過提供凝血因子Xa的強力抑制劑以滿足針對凝血Xa的選擇性和強力抑制劑的現實需求。
