PAN, Jing,POWELL, Jan,CHARNAS, Lawrence,WRIGHT, Teresa Leah,PFEIFER, Richard,SHAHROKH, Zahra,CALIAS, Pericles,MCCAULEY, Thomas
申请号：
PE0005032017
公开号：
PE09382017A1
申请日:
2011.06.25
申请国别(地区):
PE
年份:
2017
代理人:
摘要：
Refers to a Pharmaceutical composition comprising a lysosomal Enzyme at a concentration of 10mg \/ ml or greater and a buffering Agent, comprising a phosphate concentration up to 50mm, which is selected from the lysosomal Enzyme iduronate-2-sulfatase (I2S), arilsulfata recombinant SA (ASA), heparan n-sulfatase (HNS)Alpha-n-acetylglucosaminidase (NAGLU) and beta Galactosidase (GLC). Said composition is useful in the treatment of lysosomal Storage DisordersSe refiere a una composicion farmaceutica que comprende una enzima lisosomal a una concentracion de o mayor que 10mg/mL y un agente amortiguador, que comprende fosfato a una concentracion de hasta 50mM, donde la enzima lisosomal se selecciona de iduronato-2-sulfatasa recombinante (I2S), arilsulfatasa A (ASA), heparan N-sulfatasa (HNS), alfa-N-acetilglucosaminidasa (Naglu) y beta-galactosidasa (GLC). Dicha composicion es util en el tratamiento de trastornos de almacenamiento lisosomal
