MITCHELL S. STEINER,KAREN A. VEVERKA,DUANE D. MILLER,JAMES T. DALTON,KIWON CHUNG,WENQING GAO
申请号：
BR0307699
公开号：
BRPI0307699A2
申请日:
2003.02.06
申请国别(地区):
BR
年份:
2015
代理人:
摘要：
This invention provides a method of treating, preventing, suppressing, inhibiting or reducing the incidence of benign prostate hyperplasia in a male subject, by administering to the subject a selective androgen receptor modulator (SARM) and/or its analog, derivative, isomer, metabolite, pharmaceutically acceptable salt, pharmaceutical product, hydrate, N-oxide, or any combination thereof as described herein. This invention also provides a method of treating a subject suffering from hair loss, comprising the step of administering to the subject a therapeutically effective amount of a 5-&alpha； reductase enzyme type 1 and/or type 2 inhibitor, wherein said inhibitor is a selective androgen receptor modulator (SARM) and/or its analog, derivative, isomer, metabolite, pharmaceutically acceptable salt, pharmaceutical product, hydrate, N-oxide, or any combination thereof as described herein. This invention also provides a method of inhibiting a 5-&alpha； reductase type 1 and/or type 2 enzyme, comprising contacting the enzyme with an effective 5-&alpha； reductase inhibitory amount of a selective androgen receptor modulator (SARM) and/or its analog, derivative, isomer, metabolite, pharmaceutically acceptable salt, pharmaceutical product, hydrate, N-oxide, or any combination thereof, as described herein.
