JI, JINGJING,CAI, ZHENWEI,SUI, ZHIHUA,PADYANA, ANIL KUMAR,LIU, TAO,KUNG, CHARLES,CIANCHETTA, GIOVANNI,CUI, DAWEI
申请号：
ARP180102347
公开号：
AR112475A1
申请日:
2018.08.15
申请国别(地区):
AR
年份:
2019
代理人:
摘要：
1. Formula compound (1) method for modularizing pkm2 activity. These compounds are represented by formula (1), where R1,R2,L1,And L are by definition. 1. Characteristic 1: the method of transforming the activity of piruvato quinasa M2 (pkm2) into the object required by the characteristic, which requires the effective management of a formula compound (1) or a pharmaceutically acceptable salt, in which q is hydrogen, an alternative tar, Alternative alquenilo, alternative asphalt, alternative cyclopentanediol, alternative heterocyclic alternative, alternative arilo or alternative heteromorphic alternative； R1 is hydrogen, alternative alternative, alternative halide alternative,Alternative algae, alternative alternative alternative asphalt, alternative cyclopentyl, alternative heterocycle, alternative arilo, - or750606；,-C（=O）R7580801；Or a nitrogen protected group； 11 is a combination, optional alternative to tar, or-- yes.-S-CH832222---S（=O）CH83222-，-S（=O）8322；Ch8322-，- he...-NrºC（=O）-，-C（=O）nrº-，-C (=O)-OC (=O)-C（=O）o-，-NrºC（=O）o-，-OC（=O）Nrº-，-NrºC（=O）NrºC-，-OC（R83088）83222-，-C（R830808）8322；O-，-NrºC（R83088）8322-，-C（R830808）8322；-Nrº-，-S（=O）8322-，-S (=O)-S（=O）8322；O-，-O（=O）8322-，-S (= O) or--O (=O)-S（=O）8322；-Nr-NrºS（=O）8322-，-S（=O）nrº-，-NrºS（=O）-，-NrºS（=O）8322；-O-，-OS（=O）8322；Nrº-，-NrºS（=O）o-，-O（=O）nrº-，That is to say, that's what it means.The connection point of a / R2 is on the left； L2 is a combination, alternative asphalt, (= O),-S（=O）8322-，This is life. This is life.Among them, the joint point of Q is on the right side； R2 is hydrogen, halogen, optional tar, optional alcoxi, optional alquinilo, optional tar, optional ring armour oil, optional alternative cycle, optional arilo, Or alternative heteromorphism, or a nitrogen protection group when l-nr-3-NrºC（=O）-，-NrºC（=O）o-，-NrºC（R83088）8322-，-NrºS（=O）83222-，NrºS（=O）-，-NrºC（=O）NrºC-，-NrºS（=O）8322；-O-，That's it, that's it.An oxygen protection group when I'm - O--OC (=O)-OC（=O）Nrº-，-OC（R83088）83222-，-O（=O）8322-，-OS（=
