A method of manufacturing a sheet formed, in a predetermined portion of the sheet, with a region having a different flexibility property, the sheet configuring an absorbent article, the method includes: rotating in a circumferential direction both a first roll formed with a protruding portion group in a predetermined area of an outer circumferential face and a second roll arranged with an outer circumferential face opposing the first roll, forming, in the sheet, a region with the different flexibility property by passing the sheet in between the first roll and the second roll, and sandwiching the sheet with the protruding portion group and the outer circumferential face of the second roll, wherein the protruding portion group has a plurality of rows of protruding portion rows with intervals therebetween in the circumferential direction, each of the protruding portion rows including a plurality of protruding portions aligned along a rotational axis direction of the first roll, wherein a position of a downstream end in the circumferential direction of at least one protruding portion of the protruding portions configuring the protruding portion row positioned most downstream of the protruding portion group in the circumferential direction is arranged shifted from a position of a downstream end of another protruding portion configuring the protruding portion row.