Crystal form of neptinib di-p-methylbenzenesulfonate, preparation method thereof, and pharmaceutical composition containing same

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专利权人:

发明人:

Tian Tang,Feng Jin,Yanqing Wang,Jing Wu,Xiarou Liu,Jingan Yang,Hanlin Feng,Lin Yu

申请号：

US15539070

公开号：

US09957237B2

申请日:

2015.12.22

申请国别(地区):

US

年份:

2018

代理人:

摘要：

Provided is a composition of N-[4-[(3-chloro-4-fluorophenyl)amino]-7-[3-(ethoxy)-6-quinazolinyl]-4-(dimethylamino)-2-butenamide p-toluene sulfonate 1.5 hydrate α-polymorph. The α-polymorph has a stable form, a defined melting point, a good chemical stability, and a good endurance to high temperature and light irradiation, and is suitable for pharmaceutical use.

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