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2,4-pyrimidinediamine compounds for the treatment of inflammatory disorders
专利权人:
Rigel Pharmaceuticals; Inc.
发明人:
GURURAJA, Tarikere,PAYAN, Donald,TSO, Kin,KINOSHITA, Taisei,DING, Rongxian,SINGH, Rajinder,YUNG, Stephanie,LI, Hui,MASUDA, Esteban
申请号:
ES10732053
公开号:
ES2618889T3
申请日:
2010.01.13
申请国别(地区):
ES
年份:
2017
代理人:
摘要:
A compound according to the formula: ** Formula ** in which: X represents (CH2) m, in which m is an integer from 1 to 4 and one or more CH2 are optionally replaced by O, S or N (R01), wherein R01 represents H, C1-C7 alkyl or C3-C8 cycloalkyl; Y represents (CH2) n, in which n is an integer from 2 to 5, and one or more CH2 are optionally replaced by O, S or N (R02), in which R02 represents H, C1-C7 alkyl or C3-C8 cycloalkyl; Z represents N (R1), O or S, wherein R1 represents H, C1-C7 alkyl or C3-C8 cycloalkyl; represents a link having an endo configuration, an exo configuration or a mixture thereof; p is 0 or 1; R2 represents H, C1-C7 alkyl or C2-C8 alkanoyl; R3 represents F; R4 represents H, C1-C7 alkyl or C2-C8 alkanoyl; and R5 represents one of the following formulas: ** Formula ** in which R6 represents halogen, cyano, C1-C7 alkyl, C1-C7 haloalkyl, C1-C7 alkoxy or C1-C7 haloalkoxy; and R7 represents H, C1-C7 alkyl, C1-C7 haloalkyl, C1-C7 alkoxy, C1-C7 haloalkoxy, C3-C8 cycloalkyl, -SO2- C3-C8 cycloalkyl, C3-C8-SO2-R8 cycloalkyl, C3- cycloalkyl C8, -SO2-C3-C8 cycloalkenyl, C3-C8-SO2- R8 cycloalkenyl, aryl, -SO2-aryl, aryl-SO2-R8, a heterocyclic group, a -SO2-heterocyclic group, a heterocyclic group-SO2- R8 or -SO2-NR9R10, wherein each of R8 and R9 independently represents C1-C7 alkyl or C3-C8 cycloalkyl and R10 represents H, C1-C7 alkyl or C3-C8 cycloalkyl; or R6 and R7 combine to form a ring together with the carbon atoms to which they are linked; wherein "cycloalkyl" indicates a monocyclic or bicyclic alkyl; and wherein "cycloalkenyl" indicates a monocyclic or bicyclic alkenyl.Un compuesto de acuerdo con la fórmula:**Fórmula** en la que: X representa (CH2)m, en el 10 que m es un número entero de 1 a 4 y uno o más CH2 están opcionalmente reemplazados por O, S o N(R01), en el que R01 representa H, alquilo C1-C7 o cicloalquilo C3-C8; Y representa (CH2)n, en el que n es un número entero de 2 a 5, y uno o más CH2 están opcionalmente reemplazados por O, S o N(R02), en
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