Xiaoxia Wang,Labros George Meimetis,Matthew Bruce Nodwell,Raymond Andersen
申请号：
US13817106
公开号：
US09000050B2
申请日:
2011.08.22
申请国别(地区):
US
年份:
2015
代理人:
摘要：
Compounds of structure (I): including stereoisomers and pharmaceutically acceptable salts thereof, wherein R1, R2 and A are as defined herein are disclosed. Such compounds have enhanced water solubility and have activity as SHIP1 modulators, and thus may be used to treat any of a variety of diseases, disorders or conditions that would benefit from SHIP1 modulation. Enantioselective methods for preparation of compounds of structure (I), compositions comprising a compound of structure (I) in combination with a pharmaceutically acceptable carrier or diluents and methods of SHIP1 modulation by administration of such compounds to an animal in need thereof are also disclosed.
