SELS DE PYRIDINIUM AZO-QUATERNAIRE AYANT UNE EFFICACITE ANTIBACTERIENNE RENFORCEE PAR DES ACIDES, PROCEDES D'UTILISATION, PROCEDES DE SYNTHESES ET LEURS UTILISATIONS
A new azo-type quaternary pyridinium salt (Azo-QPS) shows enhanced activity at acidic conditions (e.g., pH = 5)； in neutral or basic conditions, this new Azo-QPS shows a much lower level (2 - 50 times lower) anti-bacterial activity. The use of such a "stimulus- enhance" antibiotic can response to the proliferation of bacteria directly. It helps reduce or prevent the build-up of potent antibacterial agents in the oral environment. The antibacterial properties of Azo-QPS are "activated" when the environmental pH becomes acidic； this acidic pH may be indicative of the accumulation of Streptococcus mutans, or the initiation of tooth decay.
